Question

Describe in detail how naive B lymphocytes become a plasma cell

Answer 1

Answer )

let me answer this in short first

B cells help us by providing adaptive immunity, they bind with antigens, proliferate and differentiate into Memory B cells and plasma cells . Plasma Cells secrete the anotibodies which help to ultimately destroy the antigens.

Now lets see in detail, how the following happens,

B cells have the ability to defend us against specific antigens. Antigens have the ability to provoke an immune response in the body.

On the antigen surface, coats the epitypes, these are those parts that are recignised by the immune system.

B cells are originaly developed from the B lymphocytes while they originate and mature in the Red Bone marrow. They then develop immunocompetence after migrating, this helps them to provide the adaptive immune responses.

The cell synthesises uniique cell receptors into its plasma membrane which is commonly called Immunoglobulins.

The receptors are needed to recognise the individual antigens, when the b cells bind on to these receptors, they migrate to the lymph nodes of the spleen.

now when an antigen invades into the body,, it encounters on many ill fitting receptor until it finds the one on which it sits exactly , therefore the epitopes fit perfectly well on the b cell receptors.

When this happens, the entire thing is taken or grasped into the cell and endocytosis occurs ( Phagocytosis (eating away inside the cell )) occurs leading to it breaking down into tiny peptide molecules whoich leads to the formation of MH2 complex which is then projected out of the cell onto its plasma membrane.

The T cells is recignised by the MH2 complex, which leads to the proliferation and multiplication of the B cells. now the B cells become active and differentiate to form 'Specialised cells' and 'Effector B cells ' also known as PLASMA CELLS

The secondary immune response leads to the formation of the MemoryB cells, whcih makes sure that the immunity is pprovided to the body if ever the same antigen enters in the system again by destroying that antigen before it progresses

Plasma cells ( or Effector B cells ) secrete thousands of antibodies similar to the receptor molecules of the original b cell, the antibodies will only combine with the antigenn which had originally activated the b cells. The antibodies leave the lymph nodes and get circulated throughout the bosy as a part of the humoral ( blood realted ) immunity, this is where they encounter many antigens and they get locked on to each other which ultimately leads to the death of the antigens.

Therefore the B cells needs to give rise to the Effector b cells or plasma cells for providing the required immunity to the body.

i hope i was able to help you with the answers !:)