In: Chemistry
Biochemistry: For parts a - d below, state whether or not the bond angles are observed (circle one) for protein secondary structures, and if so, state what kind of secondary structures.
a) φ = +9 0° Observed/ Not observed; Secondary Structure: ψ = - 45°
b) φ = - 130 ° Observed/ Not observed; Secondary Structure: ψ = +130 °
c) φ = - 60 ° Observed/ Not observed; Secondary Structure: ψ = - 50 °
d) φ = - 90 ° Observed/ Not observed; Secondary Structure: ψ = - 150°
Ans. According to Ramachandran plot, the secondary structures of proteins may have only a certain set of phi and psi angles which makes them thermodynamically stable in the specified conformation.
Correct option. c. Only this set of phi and psi angles are permitted (closest) in Ramachandran plot.
Given, Phi = -600 , psi = - 500. In Ramachandran plot, the closest secondary structure to it is right-handed alpha-helix (phi = -570 , psi = -470).
Options a, b, and d are not permitted by Ramachandran plot.