BioChemistry Problem State whether the Hill Coefficient (N) is positive or negative? Explain your reasoning in...

BioChemistry Problem

State whether the Hill Coefficient (N) is positive or negative? Explain your reasoning in each case.

(a) The protein has multiple subunits, each with a single ligand-binding site. Binding of ligand to one site increases the binding affinity of other sites for the ligand.

(b) The protein is a single polypeptide with two ligand-binding sites, site one causes a structural change that decreases affinity for the second ligand.

(c) A molecule binds to a protein and inhibits binding of the natural ligand.

(d) The protein has two subunits and as one ligand binds, the second binds with lower affinity.

Expert Solution

Hill coefficient :- It is a measurement of cooperativity of substrate binding to the protein. It describe the fraction of macromolecules saturated by ligand.

When N value is greater than 1 suggest two or more binding sites present in the protein. That mean positive cooperativity present . And also shows positive cooperativity binding of one ligand facilitates binding of other ligand at other site of the multimeric receptor.

Answer with reason is as follows :-

gladiator answered 8 months ago

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