Question

Which of the following statements does not describe the classical activation pathway of complement?

A) Initiation of the classical pathway of the complement system requires formation of an antibody antigen complex.

B) The classical pathway results in complement activation of the inflammatory response only.

C) The classical pathway converges with the alternative pathway, resulting in the same possible complement-mediated immune responses.

D) The classical pathway is an example of an adaptive immune response.

Answer 1

The classical complement pathway is one pathway out of three pathways that can activate the complement cascade which helps antibodies and phagocytic cells to attack the pathogens and to cause inflammation that is a part of immune system.It is initiated by formation of an antibody antigen complex. that uses antibodies IgG and IgM.Following the initiation some proteins helps to cleave the C3 and C5 proteins.This attracts the phagocytes to fight infection.This pathway is responsible for immune inflammatory responses.Also it is an adaptive immune system which is specific to a particular pathogen.For example Immunity against Measles is lifelong.These pathways are clinically important because it has been used for immunotherapies to destroy the HIV virus infected cells.This is also found to destroy Methicillin-resistant Staphylococcus aureus.Lack of this pathway can lead to angidema.The statement that does not describe the classical activation pathway of complement is c)The classical pathway converges with the alternative pathway, resulting in the same possible complement-mediated immune responses.All the other options are true.