1. compare and contrast the classic and alternative pathway of complement activation. which pathway is most...

1. compare and contrast the classic and alternative pathway of complement activation. which pathway is most directly tied in with the immune response?
2. How is a person's susceptibility to infection altered by complement deficiencies?

Expert Solution

Ques num-1

	Classical pathway	Alternative pathway
Type of immunity	Acquired (Specifc)	Innate(non-specific)
Initiation	Antigen- Antibody complex	microbial components (e.g. endotoxin)
Role of antibodies	Needed for initiatiom (activation of C1)	no role
Role of properdin	no role	Needed for activaation of C3
C3 convertase	C4b2b	C3bBb
C5 convertase	C4b2b3b	C3bBb3b
Involved components	C1-C9	Factor B, Factor D, properdin, C3,5-9

MAC(C5b6789)

formed

*The classical complement pathway typically requires antigen- antibody complexes(immune complexes) for activation (for specific immune response), whereas the alternative pathway can be activated by C3 hydrolysis, foreign material, pathogens or damaged cells

*The classical complement pathway is initiated by antigen- antibody complexes with the antibody isotype IgG and IgM.

Ques Num 2:

The mechanism of complement deficiency consists of: C2: In regard to C2 deficiency, about 5 different mutations in the C2 gene are responsible. In turn, immune function decrease and infection oppurtunities increase, therefore, no C2 protein which can help make C3- convertase is produced

gladiator answered 2 months ago

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