Which of the following does not occur at the initiation of transcription? A. TFIID is the...

Which of the following does not occur at the initiation of transcription?

A. TFIID is the first component of the pre-initiation complex to bind the promoter.

B. TFIIB binds to the promoter. first and helps RNA polymerase II initiate transcription.

C. When TBP binds the TATA box it causes the DNA to bend sharply.

D. TBP is part of TFIID

Expert Solution

There are 4 statements about transcription initiation in the question

A. TFIID is the first component of the pre - initiation complex to bind the promoter.

The statement is correct. TFIID is the first protein to bind the DNA during formation of pre initiation complex. When TFIID binds to the TATA box in the promoter region initiates recruitment of other factors for initiation.

B. TFIIB binds to the promoter first and helps RNA polymerase II initiate transcription.

The statement is incorrect. TFIID is the one which binds to the promoter first.

C. When TBP binds the TATA box it causes DNA to bend sharply.

The statement is True. TATA Binding Protein / TBP is a part of TFIID. TBP is involved in DNA melting by bending DNA by 80 degrees.

D. TBP is a part of TFIID.

The statement is True. TATA Binding Protein / TBP is a part of TFIID. TBP is a subunit of this transcription factor and it binds to TATA box.

Option B is the answer. It doesnot occur during initiation of transcription.

TFIIB BINDS TO THE PROMOTER FIRST AND HELPS RNA POLYMERASE II INITIATE TRANSCRIPTION. is the answer.

gladiator answered 2 years ago

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