Question

would the mechanism of action for testosterrone be its clinical uses? please explain its mechansim of a action

Answer 1

Testosterone is the principle male sex hormone and is responsible for reproductive growth and development in male vertebrates. Yes the testosterone has clinical uses..

Mechanism of action

Testosterone either activates androgen receptors in its unchanged form or gets converted to 5α-dihydrotestosterone (DHT) by the enzyme 5α-reductase and then binds to androgen receptors. Once bound, the receptor-hormone complex moves into the cell nucleus and binds to specific genes sequences on the cellular DNA called hormone response elements. This modifies the DNA transcription and synthesis of various proteins, thereby giving rise to the androgenergic effects exerted by testosterone.

Testosterone may also be converted to the female sex hormone estradiol, the most important estrogen in female reproductive development and bone health....

The effects of the hormone are exerted in two main ways:

• Testosterone can activate the androgen receptor itself or after conversion to 5α-dihydrotestosterone (DHT) by the enzyme 5α-reductase.
• Testosterone can also be converted into the sex hormone estradiol (by the enzyme aromatase), the most important of the estrogens in reproductive function and bone health in females....

Actions of testosterone

Testosterone plays a major role in the growth and development of the male reproductive organs such as the testes and prostate.

Anabolic effects of testosterone - Testosterone is the primary anabolic steroid. It promotes an increase is muscle mass and strength. Testosterone is also responsible for the mass, density and strength of bone. In males, an age-related decline in testosterone increases the risk of bone disorders such as osteoporosis.

Androgenergic effects - The growth of primary sexual characteristics such as the pens and testes are mediated by testosterone both while the baby forms in the womb and during puberty.

Secondary sexual characteristics mediated by testosterone include deepening of the voice and growth of facial, armpit, chest and pubic hair....

Clinical use-

Testosterone (T) is a medication and naturally occurring steroid hormone. It is used to treat male hypogonadism, gender dysphoria, and certain types of breast cancer. It may also be used to increase athletic ability in the form of doping.