Question

In: Anatomy and Physiology

A gene codes for a proinsulin protein, which is then cleaved into insulin. This is an...

A gene codes for a proinsulin protein, which is then cleaved into insulin. This is an example of:

A. A post-translational modification

B. Transcription

C. Processing of mRNA

D. Translation

Solutions

Expert Solution

Ans:-

A) post translational modification.

Post-translational modification of tertiary structure of Insulin

    Preproinsulin is transcribed as a 110 amino acid chain. Removal of the signal peptide produces Proinsulin. Formation of disulfide bonds between the A- & B-chain components, and removal of the intervening C-chain, produces a biologically active Insulin molecule comprising 51 amino acids, less than half of the original translation product.

Transcription is the process in which a gene's DNA sequence is copied (transcribed) to make an RNA molecule. ... RNA polymerase uses one of the DNA strands (the template strand) as a template to make a new, complementary RNA molecule. Transcription ends in a process called termination.

Translation is the process that takes the information passed from DNA as messenger RNA and turns it into a series of amino acids bound together with peptide bonds. ... The ribosome is the site of this action, just as RNA polymerase was the site of mRNA synthesis

  • Pre-mRNA Processing. The eukaryotic pre-mRNA undergoes extensive processing before it is ready to be translated. ...
  • 5′ Capping. ...
  • 3′ Poly-A Tail. ...
  • Pre-mRNA Splicing. ...
  • Discovery of Introns. ...
  • Intron Processing.

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