In: Anatomy and Physiology
A gene codes for a proinsulin protein, which is then cleaved into insulin. This is an example of:
A. A post-translational modification
B. Transcription
C. Processing of mRNA
D. Translation
Ans:-
A) post translational modification.
Post-translational modification of tertiary structure of Insulin
Preproinsulin is transcribed as a 110 amino acid chain. Removal of the signal peptide produces Proinsulin. Formation of disulfide bonds between the A- & B-chain components, and removal of the intervening C-chain, produces a biologically active Insulin molecule comprising 51 amino acids, less than half of the original translation product.
Transcription is the process in which a gene's DNA sequence is copied (transcribed) to make an RNA molecule. ... RNA polymerase uses one of the DNA strands (the template strand) as a template to make a new, complementary RNA molecule. Transcription ends in a process called termination.
Translation is the process that takes the information passed from DNA as messenger RNA and turns it into a series of amino acids bound together with peptide bonds. ... The ribosome is the site of this action, just as RNA polymerase was the site of mRNA synthesis