Question

A mutation in the gene encoding shugoshin results in a defective shugoshin protein. Which of the following could be a potential result in meiosis I?

1) Homologous chromosomes will stay together in meiosis I

2) Cohesin will cause sister chromatids to stick together throughout meiosis

3) Sister chromatids will stick together in meiosis I but not in meiosis II

4) Sister chromatids will separate in meiosis I

Answer 1

• Cohesin will cause sister chromatids to stick together throughout meiosis.

Because Cohesins are also involved in cellular responses to DNA damage. cohesins are employed in DSBs; they participate in the ataxia-telangiectasia mutant (ATM) pathway to damage the signal of the DNA translocation and are essential for survival after the wet. Two different members of the cohesins contribute to the repair process: cohesins act to hold the sisters together during breaks and integrators are also recruited to chromatin around the break itself. After the insertion of DSBs, cohesins are recruited to these sites through a response pathway to DNA damage. Because duplication between sister chromatids tends to be more efficient compared to between home chromosomes, cohesin can prevent recurrence between stars. Repressing replication between homesteads is important in preventing chromosome instability and rearrangements such as false replication and loss of heterozygosity.