Question

In: Biology

Whats the effect of the reeler mutation on cell-cell interaction

Whats the effect of the reeler mutation on cell-cell interaction

Solutions

Expert Solution

Cell cell interaction represents the interactions between the cell surfaces that plays the major role in function and development of multicellular organisms. Interactions means communication for the cells to coordinate and function based on changes occurs, neuronal signal inputs, inflammatory responses other communication of inhibitory and excitatory actions.

Reeler is named after a mouse which has characteristics of reeling gait. The reeler gait caused by the underdevelopment of cerebellum which is important for movement in mouse. This type of mutation is either autosomal or recessive.

Reelin is a extracellular matrix glycoprotein. By cell cell interactions it helps in the positioning and neural migrations in brain. The RELN gene in mouse is located on chromosome 5 and in humans it is located on chromosome 7.

Reeler mutation: The reln mutations results in lack of reelin which affects the positioning and neuronal migration in brain causing the altered cell cell interactions. For example the disease are found associated with reeler mutation are Schizophrenia, Autism, Alzheimer's, Lissencephaly, Bipolar disorders, temporal lobe epilepsy etc.

Example in temporal lobe epilepsy: Granule cell dispersion - the prolonged seizure in rat model due to loss of reelin expresing interneurons and subsequent ectopic chain migration, without reelin they chain migrating failed to deattach properly. Thus the reeler mutation affects the positioning and neuronal migration in brain via cell cell interactions resulting in neuronal diseases. Neurodevelopmental dissorders like Autism, neurogenerative disorders like Alzheimer's etc..

Thankyou...


Related Solutions

Whats the difference between fracture surfaces of ductile and brittle materials? Whats the effect of axial...
Whats the difference between fracture surfaces of ductile and brittle materials? Whats the effect of axial load verse torsional load on the fracture surface of ductile and brittle materials.
Whats the difference between cell motility and intracellular motility?
Whats the difference between cell motility and intracellular motility?
Question 20 An example of a suppressor mutation would be A mutation that suppresses cell growth...
Question 20 An example of a suppressor mutation would be A mutation that suppresses cell growth An intergenic mutation that increases the activity of a protein performing a different function as the mutated protein An intragenic mutation that restores the inactive protein's structure An intergenic mutation that activates a transcription factor that increases the expression of a normal protein Question 23 The mechanism for reactive oxygen species to cause mutation is the reactive oxygen species stabilize different tautomeric forms of...
QUESTION 5 In a factorial design, a main effect is the 1. effect of the interaction...
QUESTION 5 In a factorial design, a main effect is the 1. effect of the interaction between two variables. 2. effect of one independent variable at one level of the other independent variable. 3. effect of one independent variable averaged over the levels of the other independent variable. 4. only effect of interest QUESTION 11 The overall effect of an independent variable ignoring other independent variables is called a(n) ____________. 1. collapsed effect 2. interaction 3. main effect 4. omnibus...
Describe the effect of a mutation in the gene that encodes for the C3 protein of...
Describe the effect of a mutation in the gene that encodes for the C3 protein of the complement pathway.
Explain how the sickle cell mutation results in the symptoms of the disease?
Explain how the sickle cell mutation results in the symptoms of the disease?
Why is a mutation in a signaling pathway not sufficient to create a cancer cell.
Why is a mutation in a signaling pathway not sufficient to create a cancer cell.
Describe the pattern in a line graph that indicates the presence of an interaction effect in...
Describe the pattern in a line graph that indicates the presence of an interaction effect in a factorial design.
Describe the likely effect on gene expression of a mutation in the lac operon: a) that...
Describe the likely effect on gene expression of a mutation in the lac operon: a) that delegate the operator b) that mutates the lacI gene inactivating the repressor c) that the promoter mutates in the -10 region
Mutations can be classified based on either the effect of the mutation on the function of...
Mutations can be classified based on either the effect of the mutation on the function of the gene product or the location of the mutation within the chromosomes. Explain the difference.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT