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Question 20 An example of a suppressor mutation would be A mutation that suppresses cell growth...

Question 20

An example of a suppressor mutation would be

A mutation that suppresses cell growth

An intergenic mutation that increases the activity of a protein performing a different function as the mutated protein

An intragenic mutation that restores the inactive protein's structure

An intergenic mutation that activates a transcription factor that increases the expression of a normal protein

Question 23

The mechanism for reactive oxygen species to cause mutation is

the reactive oxygen species stabilize different tautomeric forms of the bases causing inappropriate pairing

thymine bases are dimerized which causes a break in the DNA which is not repaired correctly

guanine is depurinated by the reactive oxygen species and if it is not repaired can result in any base being inserted

bases are oxidized to a variety of different products which might pair with a different base than the original base would have

Solutions

Expert Solution

Answer 20. A mutation is a change in nucleotides sequence in the DNA that can occur during replication and affect the protein function. There are different types of mutations

Suppressor mutation is a mutation that occurs in genes and suppresses the earlier existing mutation in the cell and restores the phenotype of a cell. Suppressor mutation can occur within the same gene having original mutation (intragenic) or can occur in some other place in the genome apart from the gene having an original mutation (intergenic). Therefore, an example of suppressor mutation would be an intragenic mutation that restores the inactive protein structure is the right answer.

A mutation that suppresses cell growth is not the right answer as suppressor mutation is compensatory in nature and compensate for the earlier existing mutation and revert the phenotype. An intergenic mutation that increases the activity of a protein performing a different function as a mutated protein is not the right answer as mutation takes place in different genes and provide the suitable alternatives to proteins to restore the prior existing phenotype. An intergenic mutation that activates a transcription factor that increases the expression of the normal protein is not the right answer as suppressor mutations do not increase or decrease the protein activity and their main is to restore the phenotype of a protein/cell which was present before the original mutation.


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