Effect of the mutation on the function of the gene
product: This type of mutation comes under gene
mutation, here a single nucleotide gets changed or deleted
from a segment of DNA. Gene mutation may occur because of base
substitution or frame shift mutation. Frame shift mutation results
in a drastic change because the whole reading frame of nucleotides
is changed. Base substitution mutation may be:
- Silent mutation: Occurs when any nucleotide gets changed into
another nucleotide but the codon also codes for same amino acids
due to degeneracy of genetic code.
- Same sense mutation: Nucleotide gets changed into another
nucleotide but the changed codon codes for the amino acid which
belongs to the same group of amino acid of previous codon hence
genotypic changes will occur but mutation will not be
expressed.
- Mis sense mutation: Here a single change in nucleotide changes
the codon and a diferent amino acid is coded. For example Sickle
cell anaemia in which glutamic acid is replaced by valine amino
acid.
- Non sense mutation: Change in nucleotide results in stop codon
as a result functional protein is not synthesized as a result
mutation will be expressed.
Location of the mutation within the
chromosomes: This type of mutation comes under
genomatic mutation, here any change in the
structure of chromosome or the number of genes present on the
chromosome is regarded as structural aberration or chromosomal
aberration. They may be because of:
- Addition or duplication: Any gene gets replicated or inserted
in the chromosome .
- Deletion: In this type, any gene or segment of a chromosome
breaks down from the chromosome and gets deleted from the
chromosome. Deletion mutation may be lethal.
- Inversion: In this type a part of DNA segement breaks as a
result it may be paracentric inversion (centromere not involved and
arm ratio does not change) or pericentric inversion (centromere
involved and arm ratio changed).