In: Anatomy and Physiology
Classify the lab tests listed by the phase of hemostasis it assesses (primary hemostasis, secondary hemostasis, fibrinolysis, inhibition):
PT, PT and INR, aPTT, bleeding time, TT, Bethesda Titer, PFA, FDP, lupus like anticoagulants, mixing studies, d-Dimers, von Willebrand factor, Fibrinogen Activity Assay, Platelet Aggregation, Factor XIII assay (Urea Solubility Test), specific factor assays, Functional Fibrinogen Assay (Clauss Method).
PRIMARY HEMOSTASIS | SECONDARY HEMOSTASIS | FIBRINOLYSIS | INHIBITION |
bleeding time | PT | FDP | Bethesda Titer |
PFA | PT and INR | d-Dimers | lupus like anticoagulant |
Platelet Aggregation | aPTT | ||
TT | |||
mixing studies | |||
von Willebrand factor | |||
Fibrinogen Activity Assay Factor XIII assay specific factor assays Functional Fibrinogen Assay |
Primary hemostasis is a procoagulation forming process associated with initiation and formation of platelet plug.
Secondary hemostasis is a procoagulation forming process associated with propagation of clotting process via extrinsic and intrinsic coagulation cascade pathways.
Fibrinolysis is the enzymatic break down of fibrin in blood clots.
Inhibitors to coagulation factors, known as circulating anti-coagulants, are antibodies that neutralize specific clotting proteins, thereby interfering with their normal function.
PT - Prothrombin Time
INR - Interational Normalized Ratio
aPTT - activated Partial Thromboplastin Time
TT - Thrombin Time
PFA - Platelet Function Assay
FDP - Fibrin and Fibrinogen Degradation Product