In: Anatomy and Physiology
Osmoregulation is defined as regulating osmotic balance in
blood.
Kidneys are main organs involved in regulation of osmotic
balance.
The nephron consists of tubules that are arranged parallel to each
other but run in opposite direction. These tubules are separated by
interstitial space which contains interstitial fluid.
The descending limb of the loop of Henle is permeable to waterand
impermeable to ions and other substances. This results in water
movement across the tubular wall into the medullary space. The
hypertonic filtrate then passes to ascending limb.
Ascending limb is impermeable to water and permeable to solutes.
This will cause solutes to move out into the medullary space making
the interstitial fluid hypotonic. This will attract water. This
will develop countercurrent mechanism.
The active transport of ions from the thick ascending limb will
create osmotic pressure. This causes water from the descending limb
to move into medullary space and makes the filtrate
hypertonic.
The countercurrent flow within the descending and ascending limb
will increase osmotic gradient between tubular fluid and
interstitial space and maintain osmotic balance.