Vitamin D
- vitamin D is a fat soluble vitamin
- it is a sterol, it contain steroid nucleus .
- its function like a hormone
FORM OF VITAMIN D
- vitamin D2 (ergocalciferol)
- vitamin D3 (cholecalciferol)
VITAMIN D UPTAKEN IN THE BODY
- During the course of cholesterol biosynthesis 7-
dehydrocholesterol is formed as an intermiate
- on the exposure to sunlight, 7 -dehyrocholesterol is converted
to cholecalciferol in the skin in dermis and epidermis.
- dark skin pigment (melanin) adversely influence the synthesis
of cholecalciferol.
- skin is thge kargest organ in the body.
- the production of vitamin D in the skin is directly proposional
to the exposure to sunlight and inversly proportional to the
pigmentation of skin
- excessive exposure to sunlight does not result in vitamin D
toxicity since excess provitamin D3 are destroyed by sunlight
itself.
- vitamin D3 maintain a calcium level in the kidney.
ROLE AND BENEFIT OF VITAMIN D
- Vitamin D help to body absorption calcium. without enough
sunshine vitamin, bone can become thin, brittle.
- adequate vitamin D can reduce the risk of cancer
- deficency of vitamin D which can cause alzheimer disease.
- low levelof vitamin D which cause heart failure with high blood
pressure
- without adequate vitamin D preclampsia, gestational, diabetes,
caesarean section are more common.
- low levelof vitamin D increase the risk of inflammation and
rheumatoid arthritis.
- it can modulates cell growth.
- immune fuction
- gene regulation
ABSORPTION
- vitamin D is absorbed from the small intestine for which bile
is essential.
DISTRIBUTION
- stored in adipose tissue.
METABOLISM
- Transpotred to the liver then kidney ,where it is
activated
EXCREATION
- EXCREATED IN BILE.
- METABOLIZED TO WATER SOLUBLE METABOLITIES AND THEN EXCREATED IN
URINE AS WELL.