JL is a 59 year old male who is administered a drug via continuous IV infusion....

JL is a 59 year old male who is administered a drug via continuous IV infusion. The volume of distribution is 65 L and a half life of 10 hours. The drug concentration 31 hours after the infusion was started is reported to be 1.01 mg/L.

What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr.

_________

Expert Solution

Assume the effective plasma drug concentration is the target drug concentration or C _SS.

Rate of infusion (R) = C _SS k Vd = (1.01 mg/l) (0.693/10hr) (65 l) = 4.549 mg/hr.

queen_honey_blossom answered 2 years ago

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