A drug with a half-life of 15 hours is administered by continuous intravenous infusion. How long...

A drug with a half-life of 15 hours is administered by continuous intravenous infusion. How long will it take for the drug to reach 75% of its final steady-state level?

Solutions

Expert Solution

t1/2 is the time taken by a drug excrete 50% of its initial concentration.

The word initial concentration is very important here .

It is easy to understand this question with an example

just take a case where we have to Infuse a 100 mg of a drug into a patient and let the t1/2 of the drug be 15 hr .

so here we start the patient with 100 mg of the drug.

now in the body of the patient since t1/2 is 15 hours ,50% of this drug remains in the blood and the other 50 % is excreted from the body after end of 15 hrs

so at the end of 15 hours we get 50 mg of the drug in the body which is 50 % of what we need .

now ,the percentage of drug present in the body after next 15 hrs will be 50 % of its initial value so, here the initial value is 50mg so 50% of 50mg which is25mg( 25%) percentage.

so the final amount of drug after 30 hour will be 25 % in the body. meanwhile in the second 15 hours we give another dose of 100mg so that after this time 50 % of this 2nd dose remains the body.

and the 25 percentage of the first dose which will together make 75 percentage of the total

Nightingale answered 1 year ago

Next > < Previous

Related Solutions

A physician orders intravenous cefotetan 1 g in NS to be administered as a continuous infusion over 30 minutes.

A physician orders intravenous cefotetan 1 g in NS to be administered as a continuous infusion over 30 minutes. You have in stock 1 g vials of cefotetan dry powder.a) The instructions state that reconstituting the 1 g vial with 2 mL of NS results in a 400 mg/mL solution. What is the total volume of reconstituted solution in the vial? Round your final answer to the nearest tenth.b) What is the powder volume in this vial? Round your final...

JL is a 59 year old male who is administered a drug via continuous IV infusion....

JL is a 59 year old male who is administered a drug via continuous IV infusion. The volume of distribution is 65 L and a half life of 10 hours. The drug concentration 31 hours after the infusion was started is reported to be 1.01 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr. _________

A physician prescribes an intravenous infusion of Drug X for a patient. The drug is to...

A physician prescribes an intravenous infusion of Drug X for a patient. The drug is to be administered at a rate of 2.5 mg/min for 4 hours. The total volume of the IV solution is 250ml. Calculate the drip rate in drops per minute if the dropper set delivers 20 drops per milliliter. The rate of the infusion= ______ drops/minute

For children, heparin sodium is administered by intermittent intravenous infusion in a range of 50 to...

For children, heparin sodium is administered by intermittent intravenous infusion in a range of 50 to 100 units/kg body weight every 4 hours. For a 50-lb. child, calculate the range, inmilliliters, of a heparin sodium injection containing 5000 units/mL to be administered daily. NOTE: The answer should be 1.36 to 2.73mL heparin sodium injection

1. A physician orders 2000 units of heparin to be administered by intravenous infusion per hour. The...

1. A physician orders 2000 units of heparin to be administered by intravenous infusion per hour. The pharmacy provides a heparin IV bag containing 25,000 units of heparin in 250 ml of D5W. How many ml should be administered per minutes? 2.A male patient weighing 85 kg is placed on heparin therapy for the prevention of deep vein thrombosis after surgery. How many ml of a heparin injection containing 5000 units/ml should be administered for a loading dose of 75 units/kg? 3. Following...

20). A physician orders 4 L intravenous fluids for a dehydrated patient to be administered over a period of 24 hours using an intravenous set that delivers 15 drops/mL

20). A physician orders 4 L intravenous fluids for a dehydrated patient to be administered over a period of 24 hours using an intravenous set that delivers 15 drops/mL. Calculate the drip rate in a) drops per minute and in b) milliliters per hours.22). A physician orders a 2-g vial of a drug to be added to 500 mL. of D5W. If the administration rate is 125 mL/h, how many milligrams of the drug will a patient receive per minute?24)....

A certain first order reaction has a half-life of 0.35 hours. How long will it take...

A certain first order reaction has a half-life of 0.35 hours. How long will it take for 12.5 % of the reactant to react? For a certain first order reaction, it was found that after 35 seconds; only 15 % of the reactants had reacted. What is the numerical value of the rate constant? A certain first-order reaction has a half-life of 25 seconds. What percentage of the reactant will remain after 125 seconds? A certain first-order reaction has a...

The half-life of caffeine in the human body averages 5 hours. How long would it take...

The half-life of caffeine in the human body averages 5 hours. How long would it take a person who has had 8 cups of coffee to recover completely from caffeine overdose, and appear to only have had one cup of coffee? Show your work.

Escitalopram with half life 27 - 32 hours question 1 half life 27-32 hours Calculate how...

Escitalopram with half life 27 - 32 hours question 1 half life 27-32 hours Calculate how long it takes to eliminate 95% of a single dose of escitalopram from the body. Provide the range of values and the equation used. From the given pharmacokinetics parameter, explain which elimination model of escitalopram is likely to follow. questionB what is the mechanism of actions of escitalopram, and the affect escitalopram has on the structure of the target site Identify the molecular target...

for the drug escitalopram which has a half life of 27-32 hours what is it mechanism...

for the drug escitalopram which has a half life of 27-32 hours what is it mechanism of actions, the pharmacokinetics, it therputic use and adverse affects of escitalopram molecular target of escitalopram explain full mechanism of action of escitalopram What does escitalopram do at the molecular level? What does escitalopram do at the cellular level? What does the escitalopram at the tissue/organ level? What does this mean for the overall effect on the body? (i.e. What is the systemic effect?)?...

Subjects