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A drug for IV infusion is supplied as a 10 mL vial with a concentration of...

A drug for IV infusion is supplied as a 10 mL vial with a concentration of 10% w/v. 5 mL of this vial is transferred into an infusion bag to make a final volume of 250 mL. The infusion rate is to be 10 mL / min. How long will it take to deliver a dose of 100 mg of the drug?

Expert Solution

We have the formula,

Drops/ mt = Total Amount to be infused × Drop Factor

Time ( in minutes)

10% w/v = It means 10% by weight. It's used to depict the strength of a solution. For example Magnesium Hydroxide 10% w/w means that a given solution contains 10g of Magnesium Hydroxide in 100g of solution.

In order to deliver 100 mg of drug 10 vials of 10 ml are required i.e, 100ml

Dilution = 5 ml in 250 ml,

Hence 100 ml to be diluted in = 250/5 × 100 =5000 ml =5 Litres

Drops/ Mt = 10ml/mt

Drop factor for adult is 15

Hence as per the formula,

10ml/mt = 5000ml × 15

Time in minutes

Hence, Time in minutes = 5000 × 15 =75000/10 =7500 minutes

10

i.e, 7500/60 hrs = 125 hours

That is continuously for 125 hourd means 5 days and 20 hours (6days with 4 hours less on last day) drig needs to be administered.

5 litres is administered over 125 hours.

Nightingale answered 2 years ago

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