A mutation in the Sar1-GEF gene causes the Sar1-GEF protein to be a soluble ER protein....

A mutation in the Sar1-GEF gene causes the Sar1-GEF protein to be a soluble ER protein. What is the potential outcome?

a. Everything will be the same. No change.

b. Sar1-GDP will not be created.

c. COPII coated vesicles will not be created.

d. Vesicles destined for the cis-Golgi network will not be able to fuse with its target membrane.

Could someone expain this question? for instance if its not c, why not? isn't Sar1 responsible for building COATII vesicles, thanks a lot.

Expert Solution

Yes, Sar1 (cytosolic) and Sar1-GEF (membrane-bound) are responsible for building COPII coated vesicles and yes, c is the correct answer. If Sar1-GEF becomes soluble it will be in the ER lumen and not membrane-bound, and hence not in a position to interact with cytosolic Sar1. Absence of this interaction means absence of COPII coated vesicles.

Sar1-GDP is created when Sar1-GTP hydrolyzes the GTP, which happens whenever a vesicle coat has to be disassembled, hence it has nothing to do with mutations in the Sar1-GEF.

First option is obviously wrong, and I don't know anything about the fourth.

Figure showing interaction of Sar1-GDP with Sar1-GEF. Interaction is possible only when Sar1-GEF is transmembrane.

gladiator answered 7 months ago

A. A mutation in the Dorsal gene that causes the Dorsal protein to bind with high...

A. A mutation in the Dorsal gene that causes the Dorsal protein to bind with high affinity to all of the DNA binding sites for dorsal (remember normally there are low and high affinity sites in front of different genes that allow the effect of a gradient to proceed at the molecular level). 1)What will happen to the particular molecule, 2) what would happen at the cell(s) level, and 3) what would happen at the level of the whole body...

Describe the effect of a mutation in the gene that encodes for the C3 protein of...

Describe the effect of a mutation in the gene that encodes for the C3 protein of the complement pathway.

How impossible is it to actually code for a gene that causes a mutation for supernatural...

How impossible is it to actually code for a gene that causes a mutation for supernatural abilities such as flight or super strength? Not a hw question lol and probably a stupid question I'm just genuinely curious.

A mutation in the gene encoding shugoshin results in a defective shugoshin protein. Which of the...

A mutation in the gene encoding shugoshin results in a defective shugoshin protein. Which of the following could be a potential result in meiosis I? 1) Homologous chromosomes will stay together in meiosis I 2) Cohesin will cause sister chromatids to stick together throughout meiosis 3) Sister chromatids will stick together in meiosis I but not in meiosis II 4) Sister chromatids will separate in meiosis I

What is one way that a mutation in the gene encoding for a wild type protein...

What is one way that a mutation in the gene encoding for a wild type protein that generally binds ligands, prevent this protein from ligand binding?

A gene mutation causes sister chromatids to be separated into two daughter cells in the first...

A gene mutation causes sister chromatids to be separated into two daughter cells in the first nuclear division (Meiosis I) during meiosis. What a major defect would happen in the resulting haploid cells upon the completion of the second nuclear division (Meiosis II)

compare protein transport to ER with protein transport from ER to Golgi. what is the diffrence...

compare protein transport to ER with protein transport from ER to Golgi. what is the diffrence between the two methods?

Describe how a mutation in a gene switch can change when/where a protein is expressed. Using...

Describe how a mutation in a gene switch can change when/where a protein is expressed. Using an example, describe how that mutation could affect an organism’s fitness.

a. What effects does the W1282X mutation have on CFTR gene, CFTR expression and CFTR protein...

a. What effects does the W1282X mutation have on CFTR gene, CFTR expression and CFTR protein function? (4 marks, 4-6 sentences max.). b. What effects does the p-enhancer mutation have on CFTR gene, CFTR expression and CFTR function? (4 marks, 4-6 sentences max.)

Describe the four basic causes of evolution: natural selection, mutation, genetic drift, and gene flow. (please...

Describe the four basic causes of evolution: natural selection, mutation, genetic drift, and gene flow. (please 400-500 response)

Question