Question

In: Biology

Familial Mediterranean fever is an autosomal recessive condition, with high carrier frequencies known for multiple ethnicities:...

Familial Mediterranean fever is an autosomal recessive condition, with high carrier frequencies known for multiple ethnicities:

Armenian 1 in 8

Ashkenazi Jewish 1 in 13

Sephardic Jewish 1 in 14

Turkish 1 in 8

What are the chances of an Armenian man and a Sephardic Jewish woman having a baby who is affected with this condition?

Expert Solution

Let us first understand what is autosomal recessive disease. autosomal recessive disease means two copies of an abnormal gene must be present in order for the disease or trait to develop.

In the question, we are provided with the carrier frequencies of different ethnicity.

Carrier will have one abnormal gene and other genes will be normal.

Armenian (1/8)

Sephardic Jewish(1/14)

This information is given to us.

Now there are two parts in finding chances of having both of them affected baby with this condition.

First is what is the probability of two carriers producing a baby.(any Baby affected or not affected)

This will be

...........................................(1)

Now the second part will be finding a chance that the couple produces affected baby.

Now if you take a cross you will get 1 affected baby having both the recessive genes among 4.

So this will be ..............................................(2)

Now multiplying 1 and 2 we will get final answer that is 1/448

I hope this answer will help. Please rate the aanswer

gladiator answered 1 year ago

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