1. Familial Mediterranean fever is an autosomal recessive condition, with high carrier frequencies known for multiple...

1. Familial Mediterranean fever is an autosomal recessive condition, with high carrier frequencies known for multiple ethnicities: Armenian 1 in 8 Ashkenazi Jewish 1 in 13 Sephardic Jewish 1 in 14 Turkish 1 in 8 What are the chances of an Armenian man and a Sephardic Jewish woman having a baby who is affected with this condition?

Expert Solution

This is a simple question which can be directly solved by Hardy-Weinberg Equation, which states p2 + q2 + 2pq = 1

The methodology to solve the problem is as follows :

Now, we find the Probability of 2 carriers having an affected baby :

Now finally, the Risk of Child being affected can be calculated as :

Probability = (Carrier status of man) x (Carrier status of woman) x (Probability of 2 carriers having an affected baby)

= 0.4570 x 0.3916 x 0.25

= 0.04474

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gladiator answered 2 years ago

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