Alkaptonuria is an uncommon autosomal recessive condition. Sara and James had never heard of alkaptonuria, and...

Alkaptonuria is an uncommon autosomal recessive condition. Sara and James had never heard of alkaptonuria, and were shocked when their first child was born with the condition. Sara’s sister, Mary, and her husband, Frank, are also planning to have a family. Mary and Frank are concerned about the possibility of alkaptonuria affecting their children. The four adults (Sara, James, Mary, and Frank) seek the advice of a neighbor who is a retired physician. After discussing the family histories, the neighbour says, “I never took genetics, but I know that Sara and James must be carriers of this recessive condition. Since their first child has the condition, there is a very low chance that the next child will have it, because the odds of having two children with a recessive condition are very low. Mary and Frank have no chance of having a child with alkaptonuria, because Frank has no history of the condition.” The two couples each have a baby, and bothbabies have alkaptonuria.

What are the genotypes of the four adults?
What was the incorrect information given to Sara and James, and what is the correct information that they should have been provided?
What was the incorrect information given to Mary and Frank, and what is the correct information that they should have been provided?

Expert Solution

a. All 4 adults are carriers of the recessive allele and therefore must be heterozygous for the alleles.

b. Sara and James were told that there is a very low chance of having a second child with the same recessive condition which is entirely wrong. The genotype of the child is totally random and every time there's an equal chance of having a child with a recessive condition.

c. Mary and Frank were told that they have no chance of having a child with alkaptonuria because Frank has no history of the condition. Since, it is a recessive condition, having no history doesn't means complete absence of the condition. It could also mean the individual is a carrier of the condition (has a single recessive allele) which turns out to be true in their condition as they get a child with alkaptonuria.

gladiator answered 2 years ago

The frequency of carriers for a rare autosomal recessive genetic condition is 0.04 in a population....

The frequency of carriers for a rare autosomal recessive genetic condition is 0.04 in a population. Assuming this population is in Hardy-Weinberg equilibrium, what is the allele frequency of the recessive allele? 0.2 0.4 0.64 0.8 Not enough information is provided.

(1) Haemochromatosis is a mild autosomal recessive condition. Approximately 1 in 200 Australians have the condition,...

(1) Haemochromatosis is a mild autosomal recessive condition. Approximately 1 in 200 Australians have the condition, and approximately 1 in 7 Australians are carriers. Jane is planning on starting a family, and does not have haemochromatosis, though her mother is affected with the condition. Her father is not affected, and is not a carrier. Jane’s partner Steve does not have the condition either, but his father is a carrier (his mother is not a carrier). (a) What are the chances...

1. you are evaluating autosomal recessive condition A (alleles A and a) and B (alleles B...

1. you are evaluating autosomal recessive condition A (alleles A and a) and B (alleles B and b) which you hypothesize are on different chromosomes. You are given 7 wildtype (homozygous dominant) female flies and 7 male flies that are homozygous recessive. What genotypic ratio would you expect in the F1 generation produced? 2. you mate the F1 females with males that are homozygous recessive for both disease A and B to produce an F2 generation. What phenotypic ratio would...

In a population of 16,000 people, 67 are affected with a mild autosomal recessive condition. What...

In a population of 16,000 people, 67 are affected with a mild autosomal recessive condition. What is the estimated number of carriers for this condition in this population?

Familial Mediterranean Fever (FMF) is an autosomal recessive genetic condition due to mutations in the MEFV...

Familial Mediterranean Fever (FMF) is an autosomal recessive genetic condition due to mutations in the MEFV gene that encodes pyrin, a protein that functions in the immune inflammatory response. The following numbers are from a representative sample of individuals from Greece with their respective genotypes. (note- capital letters indicate the wildtype allele and lower-case letters represent mutant allele) 216 MEFV/MEVF 82 MEVF/mevf 4 mevf/mevf In France, the incidence of Familial Mediterranean Fever is 0.80% or 0.008. Use this to answer...

Borishphobia is an autosomal recessive inherited condition in humans that causes AP Biology students to go...

Borishphobia is an autosomal recessive inherited condition in humans that causes AP Biology students to go into convulsions whenever they see the Hardy-Weinberg formula. Complete dominance is the mode of inheritance for the alleles in this condition. In a group of 300 AP Biology students, 97 had convulsions (because they had the condition) during their first Hardy-Weinberg Problem Set. (Assume that students are a representative sample of a population at Hardy-Weinberg equilibrium.) What is the frequency of the borishphobia (b)...

1. A woman is affected with Alpha-1 antitrypsin deficiency, an autosomal recessive condition with a carrier...

1. A woman is affected with Alpha-1 antitrypsin deficiency, an autosomal recessive condition with a carrier frequency of 1 in 13. As they are planning on having children, her partner undergoes carrier testing for the condition. The result was negative, indicating that he was not found to be a carrier. The reported sensitivity of the carrier testing is 95%. What is the chance that their first child will be affected with Alpha-1 antitrypsin deficiency?

CF is an autosomal recessive condition. A population of 387 individuals has 7 people with CF....

CF is an autosomal recessive condition. A population of 387 individuals has 7 people with CF. If we assume that the CF gene is in Hardy-Weinberg equilibrium what is the estimated frequency of the CF allele? Give answer in decimal places

1. Familial Mediterranean fever is an autosomal recessive condition, with high carrier frequencies known for multiple...

1. Familial Mediterranean fever is an autosomal recessive condition, with high carrier frequencies known for multiple ethnicities: Armenian 1 in 8 Ashkenazi Jewish 1 in 13 Sephardic Jewish 1 in 14 Turkish 1 in 8 What are the chances of an Armenian man and a Sephardic Jewish woman having a baby who is affected with this condition?

PKU is a rare, fully penetrant, autosomal recessive condition in which an affected individual cannot break...

PKU is a rare, fully penetrant, autosomal recessive condition in which an affected individual cannot break down the amino acid phenylalanine. Neither Brian nor Mary has PKU, and they want to have children. They are concerned because Brian's father has PKU, and while neither of Mary's parents has PKU, her brother has PKU. Use symbols A and a. 1) What is the probability that Mary and Brian's first child will have PKU? Show work. 2) Mary and Brian have a...

Question