(1) Haemochromatosis is a mild autosomal recessive condition. Approximately 1 in 200 Australians have the condition,...

(1) Haemochromatosis is a mild autosomal recessive condition. Approximately 1 in 200 Australians have the condition, and approximately 1 in 7 Australians are carriers. Jane is planning on starting a family, and does not have haemochromatosis, though her mother is affected with the condition. Her father is not affected, and is not a carrier. Jane’s partner Steve does not have the condition either, but his father is a carrier (his mother is not a carrier).

(a) What are the chances their first child will be affected with haemochromatosis? (hint: draw a family pedigree)

(b)Unfortunately, things don't work out with Steve. Jane is now planning to have a child with Fred, who is not affected with haemochromatosis. Fred was adopted and knows nothing about his biological family, except that they are Australian. What are the chances that Jane and Fred’s first child will be affected with haemochromatosis?

Expert Solution

Answer:-

Given :- Haenochromatosis is a mild autosomal recessive condition in Australia.

Approx 1 in 200 Australian have this condition (affected )

And 1 in 7 are carrier.

Ans-a) A female Jane {carrier for condition i.e her mother is affected(have homozygous recessive allele-aa) and father is non affected(have homozygous normal allele -AA)} got married with Steve { his father is carrier and mother is non affected }

Probability of Steve to be carrier is 50% i.e 1/2.

Ans-b) unfortunately things between Jane and Steve doesn't go well .

Jane then married with Fred (adopted son ,know nothing about parents)

Chances of Fred to be carrier is 1/7 .Since 1 in 7 childrens in Australia are carrier.

gladiator answered 6 months ago

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