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Question 9 (4 pts) The genetic term “loss of function” is used to describe any mutation...

Question 9 (4 pts)

The genetic term “loss of function” is used to describe any mutation in the DNA that leads to a particular protein that cannot function. There are many reasons why a protein may not be functioning any longer…digging into your knowledge on mechanism of gene expression and gene expression regulation, describe a mutation that could lead to a loss of function mutation. Where is the mutation in the gene? What function of gene expression or gene expression regulation is it affecting? How is it leading to a loss of function for the protein encoded for within that gene?

But I’m going to restrict your answer…describe a mechanism that DOES NOT include a point mutation leading to missense, nonsense or frameshift – in other words, choose a mutation/mechanism other than a mutation that leads to a change in the protein coding region of a mature mRNA. I want you to think outside of that particular box.


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