Question

1) The most significant difference between acute and chronic pain ? explain

2)Explain the pathophysiology of rheumatoid arthritis

Answer 1

Ans:

Acute and chronic diseases have main difference is the acute disease is treatable and it's growth and prognosis is defined whereas the chronic diseases , causes are untreatable and sometime it is not understood

Acute disease last for some weeks but chronic can be upto months or lifetime.

The acute disease may present symptoms suddenly and severe in onset where as the chronic diseases grows slowly slowly for example osteoporosis.

Ans pathophysiology of rheumatoid arthritis.

Rheumatoid arthritis is a inflammatory disease in Which the joint gets affected leading to pain in joint and it a autoimmune disorders.

Pathophysiology.

Environmental factors, genetic susceptibility, articular cartilage distruction, family Factor.

In rheumatoid arthritis is occur when the immune cell attacks the own synovial lining of the membrane surrounding the joint.

Patho-.

In active RA, the synovial joints gets inflamed due to the inflammatory response invoice both innate and adaptive response. This caused the migration of the leucocytes and infiltrate the synovial components and result synovitis. Angiogenesis started due the local hypoxia conditions and cytokine.

This maintain hypercellular environment because the insufficient lymphangiogenesis. This whole.process causing the synovial architecture reorganization and fibroblasts activation and which adds to synovial joints inflammation.

Due the hyperplastic synovium, the damage to joint cartilage occur and some synovial properties which act as protection is reduced and levels of cytokine, chemikine and adhension molecule's, matrix metalloproteinase, tissue inhibitors of metalloproteinase is increase.the collagen gates defeated due to Matrix metalloproteinase and biochemical dysfunctioning leads to irreversible damage and painful joints.

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