Question

What is the effect of negative feedback and what is the relation to centrally acting sympathomimetic? Cite the reference.

Answer 1

Ans) Negative feedback loop brings a system closer to a target of stability or homeostasis.

- Negative feedback loops are responsible for the stabilization of a system, and ensure the maintenance of a steady, stable state. The response of the regulating mechanism is opposite to the output of the event.

- Sympathomimetics are drugs that mimic the stimulation of the sympathetic nervous system. They are classified as directly acting (act directly on α or β receptors), indirectly acting (act by providing more norepinephrine to act on α or β receptors), or mixed acting (act by both mechanisms).

- Sympathomimetics stimulate alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle.

- Clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, and anaphylaxis.