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In: Biology

Write the net biochemical equation for the biosynthesis of the non-essential amino acid aspartate from pyruvate,...

Write the net biochemical equation for the biosynthesis of the non-essential amino acid aspartate from pyruvate, carbon dioxide and ammonia from the necessary elementary reactions or steps. (you must include all necessary elementary steps for full credit)

Solutions

Expert Solution

The biosynthesis of aspartate is an interface between amino acid metabolism and carbohydrate metabolism. Aspartate is synthesized through a transamination reaction between oxaloacetate, an important Krebs cycle intermediate, and glutamate, an amino acid. Aspartate, in addition to its role as a proteinogenic amino acid, is a substrate in the arginine biosynthesis pathway and a precursor to the aspartate family amino acids methionine, isoleucine, asparagine, and threonine In the urea cycle, aspartate and ammonia donate amino groups leading to the formation of urea.


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