Question

how do we the PTT test to confirm that heparin therapy lasts for long time and the activation of plt causes microthrombi?

Answer 1

ANS :Partial thromboplastin time (PTT) is the time it takes for a patient's blood to form a clot as measured in seconds. It is used to measure the activity of the intrinsic pathway of the clotting cascade. PTT tests the function of all clotting factors except tissue factor and fibrin stabilizing factor. PTT is commonly used in clinical practice to monitor patient response to unfractionated heparin infusion to target therapeutic anticoagulation, and as part of a "coagulation panel" to help elucidate causes of bleeding or clotting disorders.

PTT is a blood test used to measure a patient's response to treatment with unfractionated heparin infusion. While to PTT does not measure anticoagulation directly, it measures the effect on blood clotting. Measured in seconds to clot formation, normal PTT can vary based on laboratory or institution; however, normal PTT is between 25 to 35. PTT ranges are used to classify heparin dosing schemes as low or high intensity and to ensure effective dosing. Based on the goal PTT the dose of heparin can be increased or decreased to achieve the desired effect. While protocols vary from institution to institution, the therapeutic PTT range for heparin is 60 to 100 seconds, with lower intensity dosing in the range of 60 to 80 seconds.