Question

1) what is the treatment for cholera?

2) what is the mechanism of action for the treatment?

3) what is the drug target and how does the drug modify the target

4) what effect does the treatment have on the microbe and the body

5) what are the side effects of the treatments

6) is there drugs resistance with this microbe? if so what kind of resistance?

Answer 1

1) cholera can be treated by rehydration, IV fluids and antibiotics

antibiotics such as Tetracycline,Doxycycline and Ciprofloxacin

fluid therapy given to treat fluid loss due to diarrhea and vomiting

2)mechanism of action of treatment of cholera using antibiotics is inhibition of protein synthesis by the bacteria. this can be achieved by blocking the bacterial ribosomes which are a site of protein synthesis

3)drug target is bacterial ribosomes. the drug blocks the site of protein synthesis on the ribosomes and prevents the bacteria from production of proteins

4)drugs kill the bacteria by preventing it from the production of toxins .

drugs effect the human body in the following ways:

• reduces the duration of diarrhea
• reduces the excretion of bacteria
• prevents spread of disease

5)side effects are as follows:

• nausea
• vomiting
• fever
• headache
• abdominal pain or cramps

6)yes there is drug resistance with this microbe, vibrio cholerae

vibrio cholerae has developed antibiotic resistant genes which efflux the antibiotics from the cell and make the treatment ineffective