Question

In: Anatomy and Physiology

1. What is the mechanism of action for lipid-soluble hormones? Examples of lipid-soluble hormones. 2. What...

1. What is the mechanism of action for lipid-soluble hormones? Examples of lipid-soluble hormones.

2. What is the mechanism of action for water-soluble hormones? Examples of water-soluble hormones.

Expert Solution

1) Lipid soluble Hormones :-

A lipophilic hormone is a hormone that passes through plasma membrane of a cell, binds to an intracellular receptor and changes gene expression.

For e.g. Steroid hormones :- Estrogen, progesterone, testosterone etc.

Mechanism of action :-

Lipid soluble hormones diffuse through the plasma membrane.

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Hormone binds to its receptor.

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Form hormone-receptor complex.

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In the nuclues this hormone-receptor complex binds to the receptor site on the chromatin which leads to activation of mRNA transcription.

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Expression of the gene.

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Physiological response.

2) Water soluble hormones :-

A lipophobic hormone is a hormone that cannot diffuse through plasma membrane of cell, binds to receptor on the plasma membrane of cell and exerts its action.

For e.g. Epinephrine, Norepinephrine, Insulin, Luteinizing hormone (LH) etc.

Mechanism of action :-

Water soluble hormone cannot diffuse through plasma membrane so it binds to receptor protein on the plasma membrane of the cell.

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Stimulation/Activation of the receptor.

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Intracellular signalling pathway (generation of second messengers, activation of cascade)

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Terminal protein in this signalling cascade is activated (Activation protein kinases).

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Phosphorylation of proteins.

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Physiological response.

Sydney Mullin answered 1 year ago

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