Explain the pathophysiology of a condition that involves decreased production of adrenal gland hormones.

Explain the pathophysiology of a condition that involves decreased production of adrenal gland hormones.

Expert Solution

The related condition which increases the production of adrenal gland hormones is Cushing syndrome.

Cortisol is secreted by adrenal gland and in Cushing syndrome cortisol levels are increased.

When adrenal gland is stimulated by adenocorticotrophic hormone (ACTH), adrenal gland secretes cortisol.

ACTH is produced by pituitary gland and released in response to stimulation by corticotropin releasing hormone (CRH). One of the main causes of Cushing syndrome is a cortisol-secreting adenoma in the cortex of the adrenal gland. The adenoma causes cortisol levels in the blood to be increased and produces negative feedback on the pituitary from the high cortisol levels which causes ACTH levels to be very low.

Excess of cortisol results in an increased gluconeogenesis rate and insulin resistance is increased.

Cushing syndrome can also be caused by ingesting increased cortisol based medications like prednisone.

Nightingale answered 2 years ago

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