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What class of antibiotics may cause a tendon rupture ? What makes it more likely to...

What class of antibiotics may cause a tendon rupture ? What makes it more likely to occur ? What instructions should be given to the patient when prescribing this class of antibiotic?

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Expert Solution

QUESTION: What class of antibiotics may cause tendon rupture?

ANSWER:

  • The class of antibiotic known as Fluoroquinolones may cause tendon rupture.
  • It increases the chances that a patient can injure their Achilles tendon.

QUESTION: What makes it more likely to occurs?

ANSWER:

  • Generally fluoroquinolones class of antibiotics most commonly involves in weight bearing tendons.
  • Mostly fluoroquinolones have been formulate to compromises the function of tendon which increase the risk of injury.
  • This class of antibiotic cause the tissue injury directly.
  • By stimulating local release of tissue damaging substances, it also indirectly generate toxicity which includes oxygen derived species and nitric oxide.
  • Fluoroquinolones also known as chelators of cations which deplete divalent ion necessary for suitable integrin receptor signaling.

QUESTION: What instructions should be given to the patients when prescribing this class of antibiotics?

ANSWER:

Instructions:

  • Take the medicine with a full glass of water.
  • Even if you feel better you should be keep taking your medicine until it finished.
  • If you take ofloxacin and norfloxacine, then you have to take fluoroquionlones class of antibiotics in empty stomach that means two hours after eating or thirty miniutes before eating.
  • If you take two doses, then you have to take it alternatively in day and night.
  • If you skip to take the dose then do not take it overdose to complete.

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