Question

What is the cause and most likely hormone profile of Hashimoto disease?

Answer 1

Hashimoto’s disease is an autoimmune disorder that can cause hypothyroidism, or underactive thyroid. With this disease, your immune system attacks your thyroid. The thyroid becomes damaged and can’t make enough thyroid hormones.
The exact cause of Hashimoto's is not known, but many factors are believed to play a role. They include:

Genes. People who get Hashimoto's often have family members who have thyroid disease or other autoimmune diseases. This suggests a genetic component to the disease.

Hormones. Hashimoto's affects about seven times as many women as men, suggesting that sex hormones may play a role. Furthermore, some women have thyroid problems during the first year after having a baby. Although the problem usually goes away, as many as 20% of these women develop Hashimoto's years later.
Excessive iodine. Research suggests certain drugs and too much iodine, a trace element required by your body to make thyroid hormones, may trigger thyroid disease in susceptible people.

Radiation exposure. Increased cases of thyroid disease have been reported in people exposed to radiation

The most common laboratory findings demonstrate an elevated thyroid-stimulating hormone (TSH) and low levels of free thyroxine (fT4), coupled with increased antithyroid peroxidase (TPO) antibodies. However, earlier on in the course of the disease, patients may exhibit signs, symptoms, and laboratory findings of hyperthyroidism or normal values. This is because the destruction of the thyroid gland cells may be intermittent.

The biochemical picture indicates raised thyroid-stimulating hormone (TSH) in response to low free T4. Low total T4 or free T4 level in the presence of an elevated TSH level confirms the diagnosis of primary hypothyroidism.