Question

70.Neurotransmitters. Catecholamines: biological role and mechanisms of action.

(please more explanatıon Im medicine student) thank you...

Answer 1

ANSWER -

catecholamine is one of the neurotransmitter which are produced in the sympathetic nervous system. catecholamine include DOPA , dopamine , norepinephrine and epinephrine. the catecholamine are synthesized in a series of enzymatic reaction beginning with the amino acid tyrosine, they are being synthesized in cytoplasm along with the help of vesicles, and stored in vesicles as secrtory molecules and released into the synnaptic cleft when required.

the basic role of the catecholamine is to increase the hyperglycimia effect in the body, they block the GLUT4 transporters which are solely responsible for the transport of insulin and also blocks the production of insulin which is done by beta cells in the pancreas, and these actions results into an decrease in the hypogylcimia effect

the synthesis of catelcoamine begins with the help of tyrosine amino acid,

tyrosine converts itself into DOPA with the help of QDPR, and the DOPA is converted into dopamine with the help of DOPA decarboxylase with th release of co2,

dopamine is converted into norepinephrine, with the help of dopamine beta hydroxylase, and then lately converted into epinephrine with the help of s-adenosylhomocysteine and s- adenosylmethionine .

this is how it is being produced and all these reactions take place in cytoplasm.