Question

There are four general classes of lipid-lowering drugs: niacin, fibric-acid derivatives, bile-acid sequestrants, and HMG-CoA reductase inhibitors.

Describe the pharmacodynamics, pharmacokinetics, and pharmacotherapeutics of each drug. When, specifically, do you use each drug? Include monitoring parameters and patient education.

Answer 1

niacin is konwn as vitamin B.there is administeration large dose of niacin decrease cholesterol level and other low density lipo protien and increase HDL,incease HDL is special character of this group of disease reduce the cardiac risk

statin drugs produce inhibitory action 3hydroxy-3methyglutyramine co enzyme (HMG-COA)reductase and thereby supress cholesterol synthesis

fibrates stimulate Beta -oxidation of fatty acid mainly in paroxysomes and mitochondria

bile acid sequestrants bind bile acid in the intestine and increase excreation of bile acid in stool resulting reduce bile acid amount retuning to liver

force the liver to produce more bile lost in stool

liver convert more chloesterol to bile acid resulting lower level of cholesterol in blood

when prescibed anti lipid medication instruct the patient for

-periodic blood investigation specially L.F.T

hbA1c and blood sugar

report the physician if cognitive sign and symptoms occur like memory loss and confusion