Question

Describe the mechanisms of action, biochemical targets and effects of these 7 lipid-lowering drugs:

Niacin

Colestipol

Torcetrapib

Avasimibe

Implitapide

Praluent

Ezetimibe

Answer 1

NIACIN: Niacin inhibits the lipolysis in the adipose tissue ,which produces the free fatty acids ,finally plasma triacylglycerol and cholesteroll are lowered .

It increases lipoprotein lipase in the adipose and muscle cells ,which increases triglycerides clearance from circulating VLDL .

Increases the half life of apolipoprotein ,which increases HDL levels.

COLESTIPOL:It binds to the bile acids int he intestine,which increases the conversion of cholesterol in to the bile acids .

It increases the clearance of LDL cholesterol from blood .

TORCETRAPIB: It inhibits cholesterylester transfer protein

It increases HDL and apolipoprotein A1 levels,it decreases LDL and apolipoprotein -B

AVASIMIBE: It inhibits enzyme cholesterol acyltransferase (ACAT)

IMPLITAPIDE: it inhibits (MTP)  microsomal triglyceride transfer protein,reduces the levels of Apolipoprotein -B and LDL .

PRALUENT:It is an monoclonal antibody that inhibits an enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9),which increases the reuptake of LDL by the liver and increases the clearance of LDL .

EZETIMIBE:It inhibits the absorption of cholesterol at the rush broder of the small intestine ,which decreases the cholesterol uptake by the liver .