Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by...

Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by mimicking the structure of mevalonate. However, it is not this inhibition that directly lowers cholesterol levels in the blood.

A) What enzymatic reaction does HMG CoA-reductase catalyze? What is important about this step of cholesterol synthesis?

B) How can statins mechanistically cause a decrease in LDL cholesterol in the blood if it is not a direct effect of decreased cellular cholesterol synthesis?

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1. List the select prototype medication for the HMG-CoA reductase inhibitors (statins).

1. List the select prototype medication for the HMG-CoA reductase inhibitors (statins).2. Describe myopathy. List the nursing actions and client education regarding myopathy.3. Heparin is the select prototype medication for parenteral anticoagulants. List 2 complications of heparin and give at least 2 nursing actions for each complication.4. What are the therapeutic uses for the oral anticoagulant warfarin?5. What are the therapeutic uses for Dabigatran?

1. List the select prototype medication for the HMG-CoA reductase inhibitors (statins). There is only one...

1. List the select prototype medication for the HMG-CoA reductase inhibitors (statins). There is only one prototype drug for this class. 2. Describe myopathy. List the nursing actions and client education regarding myopathy. 3. Heparin is the select prototype medication for parenteral anticoagulants. List 2 complications of heparin and give at least 2 nursing actions for each complication. 4. What are the therapeutic uses for the oral anticoagulant warfarin? 5. What are the therapeutic uses for Dabigatran?

How does an HMG-CoA reductase inhibitor reduce cholesterol?

There are four general classes of lipid-lowering drugs: niacin, fibric-acid derivatives, bile-acid sequestrants, and HMG-CoA reductase...

There are four general classes of lipid-lowering drugs: niacin, fibric-acid derivatives, bile-acid sequestrants, and HMG-CoA reductase inhibitors. Describe the pharmacodynamics, pharmacokinetics, and pharmacotherapeutics of each drug. When, specifically, do you use each drug? Include monitoring parameters and patient education.

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Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by...

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