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In: Biology

28) Ras is a ________, which can ______ cancer development when activated constitutively. A) Adapter protein...

28) Ras is a ________, which can ______ cancer development when activated constitutively.
A) Adapter protein of the insulin signaling pathway, promote
B) Monomeric G-protein, suppress
C) Heterotrimeric G-protein, promote
D) Monomeric G-protein, promote

29) Which of the following is not an event happened during prophase?
A) The nuclear lamina is disassembled by depolymerization of the lamin filaments.
B) Fragmentation of Golgi complex and ER.
C) Chromosomal material condenses to form compact mitotic chromosomes
D) Chromosomal microtubules attach to kinetochores.
E) All the above

30) You are comparing the properties of normal cells vs cancer cells in cell culture experiments. Which of the following you expect to find in normal cells but NOT in cancer cells based on the information you have learned?
A) They can be grown in a culture dish.
B) Their growth is promoted by addition of growth factors
C) They continue to divide even if there is DNA damage.
D) They can be epithelial origin.
E) Their growth is inhibited after a complete monolayer of cells is formed in a dish.

Solutions

Expert Solution

Answer For question no 28 : Option (D) - Monomeric G protein and promote

Explanation : Ras is a monomeric G protein, in which a small G protein (20-30 KDa) acts as molecular switch in cellular events by the shuttle of GTP and GDP binding. Unlike trimeric G Protein there are no subunits like alpha, beta or gamma.

Ras is an oncogene but it has some cellular functions also. Ras-GTPase functions in signalling pathways related to cell proliferation, integriy, adhesion, migration and apoptosis. After gain of function mutation it causes cancer.

So, Option (D) is the right answer.

Option (A) is not the right answer as Ras is not an adapter protein. Two adaptor proteins (GRB2 and SHC) are involved in activation of this monomeric G Protein.

Option (B) is not the right answer as being an oncogene, after activation (gain of function) it promotes cancer not suppress.

Option (C) is not the right answer because Ras is not a heteromeric G protein, but a monomeric G protein as it is small (20-30 KDa) and lacks subunit like alpha, beta and gamma.

gladiator answered 2 years ago
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