Phospholipase C can be activated by a G protein, which in turn leads to the formation...

Phospholipase C can be activated by a G protein, which in turn leads to the formation of Sn-diacylglycerol and inositol-1,4,5 triphosphate. correct or not

Expert Solution

Correct. Phospholipase C (PLC) cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). PLC is activated by many G protein activators. PIP2 also acts as the substrate for synthesis of the rare lipid phosphatidylinositol 3,4,5-trisphosphate (PIP3), which is used for signaling in many reactions.

DAG and IP3, are important second messengers that control diverse cellular processes and are substrates for synthesis of other important signaling molecules. When PIP2 is cleaved, DAG bounds to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 diffuses through the cytosol to bind to the IP3 receptors, particularly calcium channels in the smooth endoplasmic reticulum (ER). This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular activity.

Both DAG and IP3 are substrates for the synthesis of regulatory molecules. DAG is the substrate for the synthesis of phosphatidic acid, a regulatory molecule. IP3 is the rate-limiting substrate for the synthesis of inositol polyphosphates, which stimulate multiple protein kinases, transcription, and mRNA processing. Regulation of PLC is important in maintaining cellular physiology.

gladiator answered 1 year ago

a)Phospholipase C can be activated by a G protein, which in turn leads to the formation...

a)Phospholipase C can be activated by a G protein, which in turn leads to the formation of Sn-diacylglycerol and inositol-1,4,5 triphosphate. True/False? b)Oncogenes are mutated protooncogenes through the intermediacy of viral infection. True/False? c)Paracrine growth factors differ from hormones in their long-range of action. True/False? d)Prostanoids are extremely metabolic labile and therefore have a short lifetime. True/False? e)Carbohydrate consumption is necessary for the synthesis of triacylglycerols in adipose cells. True/Falsew? f)Thymidylate synthase: The inhibition of dihydrofolate reductase can suppress the...

28) Ras is a __, which can cancer development when activated constitutively. A) Adapter protein...

28) Ras is a ________, which can ______ cancer development when activated constitutively. A) Adapter protein of the insulin signaling pathway, promote B) Monomeric G-protein, suppress C) Heterotrimeric G-protein, promote D) Monomeric G-protein, promote 29) Which of the following is not an event happened during prophase? A) The nuclear lamina is disassembled by depolymerization of the lamin filaments. B) Fragmentation of Golgi complex and ER. C) Chromosomal material condenses to form compact mitotic chromosomes D) Chromosomal microtubules attach to kinetochores....

1. Ras is a __, which can cancer development when activated constitutively. a. adaptor protein...

1. Ras is a ________, which can ______ cancer development when activated constitutively. a. adaptor protein of the insulin signaling pathway, promote b. monomeric G protein, suppress c. heterotrimeric G protein, promote d. monomeric G protein, promote 2. The _____ kinase is essential in yeast for adding an inhibitory phosphate group to ____ when it is bound to a cyclin, which prevents the cell from entering mitosis until all conditions of the checkpoint are cleared and the phosphate group is...

40. unlike membrane G protein couple receptors some ligand gated ion channels can be directly activated...

40. unlike membrane G protein couple receptors some ligand gated ion channels can be directly activated by cytosolic second messengers. a. true b. false 2. Arrestin-mediated internalization of GPCRs terminates the GPCR signaling. The binds of arrestin is facilitated by ____ . a. Inactivation of GPCR b. GPCR in endosome c. G-protein-couple receptor kinase (GRK)-mediated phosphorylation d. dephosphorylation of GPCR 12. Checkpoints halt the progress of the cell cycle when: a. The DNA cannot be repaired in cancer cells b....

Protein Code: 1CJY which is HUMAN CYTOSOLIC PHOSPHOLIPASE A2. Please go in depth about what the...

Protein Code: 1CJY which is HUMAN CYTOSOLIC PHOSPHOLIPASE A2. Please go in depth about what the structural features are of the protein? (primary, secondary, tertiary, quaternary)

Which is common feature shared between the GG-subunit of a G-protein complex and the c-ras protein?...

Which is common feature shared between the GG-subunit of a G-protein complex and the c-ras protein? Select one: a. intrinsic GTPase activity b. membrane associated protein c. signal transduction d. All of these e. None of these.

There are seven events when G-protein coupled receptor is activated. What are those seven steps.

Upon binding to its ligand the GPCR becomes activated and Question options: inactivates G protein by...

Upon binding to its ligand the GPCR becomes activated and Question options: inactivates G protein by changing its affinity for GDP and causes it to exchange it for GTP activates G protein by phosphorylating it activates G protein by changing its affinity for GDP and causes it to exchange it for GTP activates G protein by changing its affinity for GTP and causes it to exchange it for GDP

QUESTION 1 Which of the following is an enzyme? a G protein a G protein-coupled receptor...

QUESTION 1 Which of the following is an enzyme? a G protein a G protein-coupled receptor ATP All of the above None of the above 1 points QUESTION 2 Which of the following is true for all enzymes? They alter the transition state. They decrease ΔG. They provide energy for endergonic reactions. They harness energy from ATP. 1 points QUESTION 3 The pathway of glycolysis can be found in: Anaerobic bacteria only Anaerobic species only All bacteria, but...

54. Which of these receptor classes can activate G proteins G protein coupled and ion channel...

54. Which of these receptor classes can activate G proteins G protein coupled and ion channel receptors Enzyme coupled receptors G protein coupled receptors and enzyme coupled receptors Ion channel coupled receptors G protein coupled receptors

Question