Question

Compare and contrast MHC class 1 vs MCH class 2: what are they? What do they present? Which cell lines express (have) them? Which immunity cell lines perceive (bind with) them? Which receptors are then used by those immunity cells to perceive them?

Answer 1

Compare and contrast MHC class 1 vs MHC class 2: what are they? What do they present? Which cell lines express (have) them? Which immunity cell lines perceive (bind with) them? Which receptors are then used by those immunity cells to perceive them?

Answer:- MHC ( Major Histocompatibility Complex ) are antigen presenting molecules and interact with both antigen and then with TCR (T cell receptor). There are two classes of MHC : MHC class 1 and MHC class 2.

MHC class 1	MHC class 2
MHC class 1 molecule is composed of an α chain with 3 domains (MHC-encoded) and β2-microglobulin. (not encoded in the MHC locus).	MHC class II molecule consists of two transmembrane proteins, an α-chain and a β-chain, which together form a protein with an open-ended peptide-binding groove ( both MHC-encoded).
MHC Class I cells Present endogenous antigens.	MHC class 2 cells Present exogenous antigens.
MHC class I molecules are expressed on all nucleated cells.	MHC class II molecules are expressed on antigen presenting cells such as B cells, macrophages, dendritic cells.
CD8+ (Cytotoxic) T-Cells perceive (bind with) them.	CD4+ T-helper Cells perceive (bind with) them.
MHC class I complex bind with TCR and Tc CD8 co-receptor makes binding stronger) on cytotoxic T cell.	MHC class II complex is bind with the T cell receptor (TCR) and CD4 co- receptor ( TH) on helper T cell.