Briefly describe presentation by MHC class I molecules and give 2 comparisons where MHC class II...

Briefly describe presentation by MHC class I molecules and give 2 comparisons where MHC class II presentation is different.

Expert Solution

Answer: Presentation by MHC class 1I MHC class I molecules prsent the processed cytosolic or endogenous protein antigens on the surface of cytotoxic T cells. Cytosolic antigen is degraded by proteasome into peptides which then enters rough endoplasmic reticulum via TAP (transporters associated with antigen presentation) where it binds MHC class I and transported to cell surface by vesicle mediated transport through golgi complex. The process is shown diagrammatically below in handwritten:

Comparisons where MHC I presentation differs from that by MHC II:

1. Cytoplasmic pathogen like virus which don't use its own transcriptional and translation machinery will be presented through MHC1 while pathogens which enters into the blood or are extracellular will be presented through MHCII by antigen presenting cells.

2. Processing of antigen through MHC1 occurs through proteosome while processing of antigen through MHC II occurs through endocytosis and endosome-lysosome complex.

gladiator answered 2 years ago

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