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Conduct Internet research to determine the top three prescribed diuretics. Classify the three drugs, and, for...

Conduct Internet research to determine the top three prescribed diuretics. Classify the three drugs, and, for each classification, discuss the therapeutic actions, indications, pharmacokinetics, contraindications, the most common adverse reactions, and the important drug–drug interactions. Prepare flashcards for the three medications and be prepared to present to class.

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Expert Solution

A diuretic is any substance that promotes diuresis, the increased production of urine.

Diuretics can be classified on the basis of site of action on nephron:

1) DRUG ACTION ON SITE I: carbonic anhydrase inhibitors, eg: Acetazolamide, ethozolamide.

dose: 250 gm

used in treatment of epilepsy, glucoma.

2) DRUG ACTING ON SITE III: Furosemide, Bumetanide

Dose:20-80mg once daily

It is used in the treatment of poisoning, used to reduce edema of congestive heart failure.

3) DRUG ACTING ON SITE IV: a) Thiazide, eg: Chlorthiazide: Dose 500-2000mg(oral)

                                             b) Thiazide like diuretics , eg: xipamide: Dose 20-60mg.

4) DRUG ACTING ON SITE V: (Potassium sparing diuretics)

a) Aldosterone antagonist , eg: Spironolactone: Dose: 25-50mg(oral)

It is used in hypertention, edema.

b) Directly acting , eg: Triamterene: Dose: 50-100mg(oral)

Nightingale answered 2 years ago
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