Question

Conduct Internet research to determine the top three prescribed diuretics. Classify the three drugs, and, for each classification, discuss the therapeutic actions, indications, pharmacokinetics, contraindications, the most common adverse reactions, and the important drug–drug interactions. Prepare flashcards for the three medications and be prepared to present to class.

Answer 1

Diuretics are drugs which lead to urination.

The top three prescribed diuretics aree

1. Lasix

Classification: Loop diuretic

Action: Diuretic

Pharmacokinetic:when administered orally the peak is achieved in 1-2 hour,5 minutes by IV.The bioavailability is 43-69%

Indication: High blood pressure, severe medical illness unable to take medication orally,weight loss

Contraindications: Allergic to furosemide,Pregnancy, premature baby, elderly population,nursing mother,liver disease

Adverse reactions: dizziness headache, diarrhea, constipation, anorexia, vision impairment, muscle cramps, dehydration nausea, vomiting,hyponatremia

Drug drug interactions: Desmopressin,lithium NSAIDS)

2)Aldactone

Classification: Potassium sparing diuretics

Action: diuretics

Pharmacokinetic:Bioavailability is 60 to 90% when taken with food.

Indications: High blood pressure, heart failure, edema, low potassium level)

Contraindications: any allergies, liver problems, hyperkalemia,breast feeding, pregnancy

Adverse reactions: dizziness, lightheadedness, stomach upset, headache fatigue, breast pain ,tenderness, yellowing of eye and skin,rash,itching, swelling, trouble breathing

Drug drug interactions: Dixon,lithium, cough and cold drugs

3)Diucardin

Classification:Thiazide diuretic

Action: Diuretic

Indication: congestive heart failure, hepatic cirrhosis, corticosteroid ,estrogen and in adjunctive therapy, edema

Pharmacokinetic:depend upon the site where it reaches mostly

Contraindications:renal and liver disease,sensitive, SLW

Adverse reactions: anorexia, jaundice, pancreatitis, xanthopsia,vertigo ,dizziness, orthostatic hypo tension,hyperglycemia

Drug drug interactions:anticoagulant, antihypertensive drugs corticosteroid NSAIDS, lithium and methenamine