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What is the mechanism of synthesis of phosphoribosyl pyrophosphate and what role does it play in...

What is the mechanism of synthesis of phosphoribosyl pyrophosphate and what role does it play in the cell?

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Expert Solution

Phosphoribosyl pyrophosphate (PRPP) is synthesized from the ribose-5-phosphate in the presence of ATP and ribose-phosphate diphosphokinase. The reaction follows SN2 mechanism, in which one bond is broken and another is formed synchronously. Phosphoribosyl pyrophosphate plays a key role in the synthesis of purines through salvage pathway and de novo synthesis reactions.

                                               Ribose-phosphate diphosphokinase              

Ribose-5-phosphate + ATP ------------- ---------------------------------> Phosphoribosyl pyrophosphate + AMP .

gladiator answered 2 years ago
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