Question

Instructions:

1. Search a research study with relevance to the drug therapy of diuretics with antihypertensives to effectively decrease the blood pressure.
2. Write a brief summary of the study using the format provided below.
3. Use APA format for the source/s.

Title:

Author/s:

Background:

Objectives:

Participants:

Methodology:

Results:

Recommendation:

Implication to the Nursing Profession:

Source:

Answer 1

Beta blockers with diuretics :-

Beta blockers causes retention of Sodium and water. Diuretics cases mild reduction in water volume that leads to increase in renin secretion by the kidney. The rationale for combining beta blockers with diuretics is two fold : beta blockers blunt the increase of renin in plasma that is induced by diuretics and diuretics causes the decrease in sodium and water retention that was caused by the beta blockers. The combination of diuretics and betablockers produces additive effect compare with monotherapy using either alone. A recent study assessed the safety and efficacy of antihypertensive therapy using the cardioselective beta blocker besoprolol alone or with combination of hydrochlorothiazide. The dosases of bisopolol were 2.5,5 ,10mg per day. The hydrochlorothiazide dosages were 6.25 and 25 me per day the study showed that monotherapy with either agent was more effective than placibo , but that when combination therapy was used the beneficial effect were greater than when either agent was.used alone. In same study combination therapy was associated with a low incidence of adverse effects . Side effect for combined hydrochlorothiazide in a dose of 6.5mg per day and bisoprolol in all doses include fatigue , dizziness, importance and diarrhea. When used in combination with bisoprolol and hydrochlorthiazide did not cause hypokalemia or any adverse effects on lipid profile.

Diuretics are effective antihypertensive drugs. Treatment with a diuretics such as hydrochlorothiazide results in a dose dependent blood pressure reduction that levels of with higher dosages. In long term trials diuretics have been shown to reduce the incidence of stroke, congestive heart failure, coronary artery disease and total mortality from cardiovascular disease.

Combination therapy with potassium sparring diuretics and a thiazide diuretics attempt to reduce the risk of adverse metabolic effect. Combination therapy doesn't obviate the need for serial monitoring of serum electrolytes level but it does decrease the incidence of thiazide induced hypokalemia without an increase risk of hyperkalemia. Fixed dose potassium sparring thaizides diuretics combination have been in use for more than 20 years. Current combination include spironolactone hydrochlorothiazide,triamterine hydrochlorotiazide and amiloride hydrochlorothiazide . These combination drug don't appear to differ significant in efficacy or adverse effects . The described improvement of bioavailability of maxzide over diazide has not been shown to yield improved blood vessels control.all potassium sparring thiazide diuretics combination seem to reduce blood pressure to the same degree as thiazide diuretics alone.