Question

If you take into account the amount of ATP generated by ATP synthase per molecule of NADH and
FADH2 produced in aerobic respiration, the net number of ATP molecules produced by substrate
level phosphorylation, and the fact that NADH molecules produced in the cytoplasm have to be
transported into the mitochondria, what is the predicted energy yield of (i) glycolysis and (ii) Krebs
cycle, per molecule of glucose in eukaryotic cells?   

Answer 1

Glycolysis is process of glucose to pyruvate conversion which is shown in the picture velowthere two atp used to convert glucose to two molecules of Glceraldehyde 3 phosphate and after that two glyceraldehyde 3 phosphate is converted to pyruvate by producing 4 atp and 2 nadph. Hence total 9 atp produced and 2 atp used earlier so net 7 atp by glycolysis. 1 NADPH gives 2.5 atp

Kreb cycle is start with acetyl coA is shown below

so here we can see that one glucose molecule produces two acetyl coA molecules hence we can see in figure that 2 molecules of acetyl coA 6 NADPH, 2 FADH2 and 2 GTP. Hence net 20 ATP produced from one glucose molecule.

And NADPH is transferred from cytosol to mitochondria by malate aspartate shuttle as shown below.