Question

Evidence based practice recommends the goal of oxygen therapy for a patient with COPD not be based on liters of oxygen administered, but instead an SpO2 greater --------- % during rest, sleep, and exertion

Answer 1

1.88-92% of oxygen during rest, sleep and exercise is enough for patient with COPD.

For most COPD patients, you should be aiming for an SaO2 of 88-92%, (compared with 94-98% for most acutely ill patients NOT at risk of hypercapnic respiratory failure). Mark the target saturation clearly on the drug chart.
The aim of (controlled) oxygen therapy is to raise the PaO2 without worsening the acidosis. Therefore, give oxygen at 24% (via a Venturi mask) at 2-3 L/minute or at 28% (via Venturi mask, 4 L/minute) or nasal cannula at 1-2 L/minute. Aim for oxygen saturation 88-92% for patients with a history of COPD until arterial blood gases (ABGs) have been checked

Measure ABGs within 30-60 minutes of starting supplemental oxygen or changing its concentration. If PaCO2 normal, concentration of the supplemental oxygen may be increased to 94-98%.
It is worth noting that a large-scale systematic review questioned the benefits of raising the SaO2 above 96% in acutely ill adults