Question

What are five factors that can lead to intellectual and developmental disabilities? How could each be prevented?

Answer 1

Intellectual disability is a disability that occurs before age 18. People with this disability experience significant limitations in two main areas: 1) intellectual functioning and 2) adaptive behavior (the use of everyday social and practical skills).Intellectual disability is diagnosed through the use of standardized tests of intelligence and adaptive behavior .

Intellectual disability can be caused by any condition that impairs development of the brain before birth, during birth or in the childhood years.

. The three major known causes of intellectual disability are Down syndrome, Fetal Alcohol Spectrum Disorder (FASD) and Fragile X syndrome. The causes can be categorized as follows:

• Genetic conditions - These result from abnormalities of genes inherited from parents, errors when genes combine, or from other disorders of the genes caused during pregnancy by infections, overexposure to x-rays and other factors. There are many genetic diseases associated with intellectual disability. Some examples include PKU (phenylketonuria), a single gene disorder. Due to a missing or defective enzyme, children with PKU cannot process a part of a protein called phenylalanine. Without treatment, phenylalanine builds up in the blood and causes intellectual disability. Down syndrome is an example of a chromosomal disorder. Chromosomal disorders happen sporadically and are caused by too many or too few chromosomes, or by a change in structure of a chromosome. Fragile X syndrome is a single gene disorder located on the X chromosome and is the leading inherited cause of intellectual disability.
• Problems during pregnancy - Use of alcohol or drugs by the pregnant mother can cause intellectual disability. In fact, alcohol is known to be the leading preventable cause of intellectual disability. Recent research has implicated smoking in increasing the risk of intellectual disability. Other risks include malnutrition, certain environmental toxins, and illnesses of the mother during pregnancy, such as toxoplasmosis, cytomegalovirus, rubella and syphillis.
• Problems at birth - Prematurity and low birth weight predict serious problems more often than any other conditions. Difficulties in the birth process such as temporary oxygen deprivation or birth injuries may cause intellectual disability.
• Problems after birth - Childhood diseases such as whooping cough, chicken pox, measles, and Hib disease that may lead to meningitis and encephalitis can damage the brain, as can injuries such as a blow to the head or near drowning. Lead, mercury and other environmental toxins can cause irreparable damage to the brain and nervous system.
• Poverty and cultural deprivation - Children growing up in poverty are at higher risk for malnutrition, childhood diseases, exposure to environmental health hazards and often receive inadequate health care. These factors increase the risk of intellectual disability. Also, children in disadvantaged areas may be deprived of many common cultural and educational experiences provided to other youngsters. Research suggests that such under-stimulation can result in irreversible damage and can serve as a cause of intellectual disability.

During the past 30 years, significant advances in research have prevented many cases of intellectual disability.

Early intervention programs with high-risk infants and toddlers have shown positive effects on intellectual functioning. Finally, early comprehensive prenatal care and preventive measures prior to and during pregnancy increase a woman’s chances of preventing intellectual disability. Dietary supplementation with folic acid, taken before and during pregnancy, reduces the risk of neural tube defects. Women who have phenylketonuria (PKU) should be counseled to go on a restricted phenylalanine diet three months prior to pregnancy to prevent intellectual disability in their baby.

The health of a baby can depend on how healthy a mother is before pregnancy. Ideally, she should obtain a general health assessment six months before pregnancy that includes:

• updating immunizations;
• reviewing use of medications;
• reviewing diet and vitamin supplementation, including folic acid;
• considering genetic counseling; and
• stopping use of alcohol, cigarettes
• or other tobacco forms, illegal drugs, and legal drugs not approved by the doctor.

Prenatal care should begin as soon as she suspects she is pregnant. During pregnancy, a woman can protect the developing fetus by:

• getting plenty of rest and sleep;
• eating nutritious meals;
• avoiding alcohol, cigarettes and drugs;
• avoiding people who are sick;
• wearing seat belts in a car; and
• not lifting heavy objects.

Genetic counseling should be considered if:

• the child may inherit a genetic or chromosomal disorder because of a specific condition in the family;
• a previous birth to either parent resulted in a child with a genetic disorder, unexplained intellectual diasbility or a birth defect;
• the mother has had two or more miscarriages or a baby who died in infancy;
• the mother is 35 years of age or over;
• either partner is of a race or ethnic group with a high incidence of a genetic condition; and
• the partners are blood relatives.