Question

The World Health Organization (WHO) had announced the outbreak of coronavirus disease 2019 (COVID-19) as a pandemic on 11 March 2020. With the entire world reeling under the prodigious attack of the pandemic in colossal proportions, various strategies were designed to nullify the transmission, but with little success. Preventive measures, namely social distancing, sealing off large towns, closing borders and confining people to their homes were strategically implemented. Inspire of these, the transmission rates grew unabated. Adding fuel to fire, the lack of effective antiviral drugs and vaccine further worsened the scenario. As a student in pharmaceutical engineering technology, you have greatest responsibility to propose a novel treatment or delivery system to improvise current treatment.

Thus, you are required to discuss with your team and propose potential solutions on the type of combination treatment can be provided based on literature and clinical studies that has been conducted to treat COVID-19 patients.

1. Background Controlled drug delivery system (provide literature supports)

2. Mechanism of action Controlled drug delivery system to treat covid-19 patient(With the aid of schematic diagram)

3. Material/methods Controlled drug delivery system

4. References

Answer 1

Answer :)

The drug delivery system plays a vibrant part in destroying the COVID-19 pandemic. Few choices on drug delivery are been very considered. An emulsifying system is a potential system in one of them. This system plays a vital role in reducing water compounds in direction for the virus to pursuit an environment to sink in. Emulsions are fundamentally transfer of nanometer droplets from one liquid to another.

Basic components of an Emulsifying delivery system contain liquid like oil or water, surfactant, co-surfactant, and a drug. Liquids are initially considered to be in the transportation method. Medium triglycerides with oxidation properties and solvent capacity larger for transportation are frequently the first choice. The surfactants are the film layer that simplicities lower tension surface, which helps in movement. The emulsifying factor must be high; in order to attain that, a quick spreading of formulation must be attained. The lipid bilayer must be greater than 12 for the above method to take place. Next are the co-surfactants, which help in the reduction of tension amid the film to almost negative. In respect to acclimatize that surface tension, low chain alcohol is required.

The above-mentioned method is one of the many systems such as ionization, vaccination, and lipid formulation. However, choosing any system is not the main problem. It is patient linked or target based inhibitors that are the main problems arising in the finding of the drug delivery system in the COVID-19 treatment. It is because CoVs are quickly replicating groups. Therefore, target-based apparatus with singular biology should be an area of concentration. The most refined application is viral enzyme inhibitors. An additional important aspect is testing. Meanwhile, there are limited animal models to examine it should pose a challenge.