Mr. Smith has a duodenal ulcer and a new prescription for sucralfate. He asks the nurse...

Mr. Smith has a duodenal ulcer and a new prescription for sucralfate. He asks the nurse how this medication works, and you correctly respond that it:

A. Prevents gastric acid secretion in the stomach

B. Neutralizes gastric acid after it is secreted

C. Adheres to the ulcer and protects it from gastric acid

D. Kills the bacteria which cause ulcers

Solutions

Expert Solution

The correct answer is C - adheres to the ulcer and protects it from gastric acid

Explanation

Sucralfate is made up of aluminum hydroxide and sulfated sucrose
The stomach contains high levels of hydrochloric acid.
This acid separates the sulfated sucrose from the aluminum hydroxide
Also, it undergoes polymerization into a sticky substance.
Apart from being sticky, it also has a negative charge.
The ulcer as a positive charge ( because of the proteins present in it). The negative change drug and the positive charge lesion attack each other and a polyvalent bridge is formed.
This act as a barrier against the pepsin (proteolytic enzyme) and gastric acid
it promotes the healing of the gastric ulcer.

Incorrect answers.

A. Sucralfate has no effect on gastric acid secretion. Drugs like proton pump inhibitor and histamine 2 receptor blocker reduce gastric acid secretion

B. Sucralfate can buffer acid but it is not its main mechanism of action

D Sucralfate has no action against helicobacter pylori. Drugs like amoxicillin, metronidazole, tinidazole, tetracycline and clarithromycin are effective against H. pylori

Nightingale answered 1 year ago

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